The worldwide prevalence of obesity has nearly tripled in less than fifty years.Â
If we are more informed about potential health consequences than ever before, why are more and more adults choosing unhealthy eating habits that lead to weight gain, diabetes, and heart disease?Â
Dr. Stephan Guyenet, who has spent more than a decade studying the neuroscience of body fatness, argues that most of us arenât choosing our eating habits at all.
His book, The Hungry Brain, dives into the idea that eating behaviors arenât a result of weakness or poor willpower, but of an evolutionary mismatch between our brainâs ancient programming and our current environment.Â
Today he sits down with Dotsie and Alexandra to explain how our brains are hardwired to seek the high-calorie, dopamine-releasing foods that our ancestors relied on, and why that works against us in modern society.Â
Youâll hear how your neurochemistry is influencing your eating habits, why youâre suddenly hungry for dessert after being satiated by dinner, and what you can do to overcome some of these neurological triggers that make it difficult to change the way you eat.Â
If youâve ever been frustrated by a craving or your habit of second helpings, donât miss this episode to hear why, if you want to change your stomach, you need to focus on your head.
Listen to Episode 263 with Dr. Stephan Guyenet
What we discuss in this episode:
Dotsieâs experience at the Plant-Based World Conference & Expo
How convenience, cost, and the palatable seduction of food have contributed to higher rates of obesity
Why do we have a greater eating drive than we did only a century ago? Dr. Stephan Guyenet explains how our ability to concentrate dopamine-releasing ingredients is qualitatively similar to the creation of crack cocaine
The evolutionary mismatch: How our ancestors’ drive to survive is working against us today
What do genetics have to do with our body composition and our penchant for overeating
Why you should focus on diet before exercise if youâre hoping to lose weight
Understanding the two systems of our brain and why activities like exercise require overcoming the effort barrier of System 1 and thinking with System 2
The fat regulatory system, the starvation response, and why âcalories in, calories outâ is not as simple as counting numbers on a nutrition label
The two things that slow your metabolic rate and what you can do about them
Simple things you can try to overcome your bodyâs starvation response and limit your habit of overeating

âThe greater variety of the types of foods that we have available to us, the more calories we will tend to eat at a meal, and we wonât even necessarily feel any more full.â – Dr. Stephan Guyenet
What We Discuss
- Dotsie’s experience at the Plant-Based World Conference & Expo
- How convenience, cost, and the palatable seduction of food have contributed to higher rates of obesity
- Why do we have a greater eating drive than we did only a century ago? Dr. Stephan Guyenet explains how our ability to concentrate dopamine-releasing ingredients is qualitatively similar to the creation of crack cocaine
- The evolutionary mismatch: How our ancestors’ drive to survive is working against us today
- What genetics have to do with our body composition and our penchant to overeat
- Why you should focus on diet before exercise if you’re hoping to lose weight
- Understanding the two systems of our brain and why activities like exercise require overcoming the effort barrier of System 1 and thinking with System 2
- The fat regulatory system, the starvation response, and why “calories in, calories out” is not as simple as counting numbers on a nutrition label
- The two things that slow your metabolic rate and what you can do about them
- Simple things you can try to overcome your body’s starvation response and limit your habit of overeating
- Follow Dr. Stephan Guyenet on Twitter at @whsource and on his website at StephanGuyenet.com.






